Posted By: Minerva B
Primary Scientific Article:
Gumz, M.L. et al. (2007) Secreted Frizzled-Related Protein 1 Loss Contributes to Tumor Phenotype of Clear Cell Renal Cell Carcinoma. Clinical Cancer Research; 13(16)
Gumz, M.L. et al. (2007) Secreted Frizzled-Related Protein 1 Loss Contributes to Tumor Phenotype of Clear Cell Renal Cell Carcinoma. Clinical Cancer Research; 13(16)
Blog Post #2 GPRC5A Can Be the Key to Lung Cancer
Posted By: MON
Primary Scientific Article:
Primary scientific article:Tao, Q., Fujimoto, J., Men, T., Ye, X., Deng, J., Lacroix, L. & et al. (2007, November 13 ). Identification of the Retinoic Acid – Inducible Gprc5aAs a New Lung Tumor Suppressor Gene. Journal of the National Cancer Institute, 99(22), 1668-1682.
Blog Comments
From a molecular biology standpoint, the blog that I particularly find to be interesting is Minerva B’s blog on clear cell renal carcinoma (ccRCC). I decided to comment on this blog because ccRCC is a cancer located in the kidney’s that’s on the rise. Like Minerva said in her blog, it has resistance to radiation and chemotherapy which makes it very expensive and difficult to treat. It’s a challenge to conduct studies and tests on difficult cancers like ccRCC. This post explains the studies that researchers conducted and the results that they were able to prove about the sFrP1 (Secreted Frizzled-Related Protein 1), which is a tumor suppressor gene. What I found interesting is that when the gene is turned off transcription factors are blocked. Scientist made the educated guess that if the sFRP1 gene activated by turning it on. Activating it will lessen the growth of the tumor and can even get rid of it. I find that to be a tremendous discovery, thats one of the cancers that we can possibly treat if detected early.
Primary scientific article:Tao, Q., Fujimoto, J., Men, T., Ye, X., Deng, J., Lacroix, L. & et al. (2007, November 13 ). Identification of the Retinoic Acid – Inducible Gprc5aAs a New Lung Tumor Suppressor Gene. Journal of the National Cancer Institute, 99(22), 1668-1682.
Blog Comments
From a molecular biology standpoint, the blog that I particularly find to be interesting is Minerva B’s blog on clear cell renal carcinoma (ccRCC). I decided to comment on this blog because ccRCC is a cancer located in the kidney’s that’s on the rise. Like Minerva said in her blog, it has resistance to radiation and chemotherapy which makes it very expensive and difficult to treat. It’s a challenge to conduct studies and tests on difficult cancers like ccRCC. This post explains the studies that researchers conducted and the results that they were able to prove about the sFrP1 (Secreted Frizzled-Related Protein 1), which is a tumor suppressor gene. What I found interesting is that when the gene is turned off transcription factors are blocked. Scientist made the educated guess that if the sFRP1 gene activated by turning it on. Activating it will lessen the growth of the tumor and can even get rid of it. I find that to be a tremendous discovery, thats one of the cancers that we can possibly treat if detected early.
As I red up on other blog posts, there was a common thread between Kidney Cancer Caused by "Sleeping Gene"? Rise and Shine!!!! Posted by: MinervaB and GPRC5A Can Be the Key to Lung Cancer Posted by: MON. Both of the post were written and researched by using primary articles pertaining to these cancers and their tumor suppressor gene’s. The genes that are involved are GPRC5A and sFRP1. sFRP1 functions as a tumor suppressor gene and GPRc5A is a gene is that is key to developing cancer. Both of these genes, Inhibit uncontrolled proliferation by affecting WNT, which is a signaling pathway. So far in my senior semior seminar class we have studied signaling pathways and tsg's. The common thread I see in both blogs is the signaling pathways and the tsg's that supress or inhibit uncontrolled cell proliferation.
Remaining Questions:
1.)In what way moelcularly does both tsg inhibit proiferation by affecting WNT?
2.)Sine I found a common relationship between the two blogs. Does the primary articles cite one another?
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