Pee Worried and What's the Bladder

Post 1: Pee Worried!!!

News Article:Drug Week Editors (February 11, 2005) “Fragile histidine triad gene inactivation supports bladder cancer formation.”
Primary Article:Vaccine, A., Sevignani C. , Giarnieri, E. (2004, November 15) Inactivation of the FHIT Gene Favors Bladder Cancer Development. Clinical Cancer Research Vol. 10, 7607-7612
Cited Article:Ishii, H., Mimori, K., Inoue, H. (2006, December 6) Fhit Modulates the DNA Damage Checkpoint Response. Cancer Research 66, 11287-11292


Post 2: “What’s the Bladder? A Look into Bladder Cancer and the Tumor Suppressor Gene RhoGD12”

Bladder Cancer; Endothelin axis is a target of the lung metastasis Suppressor Gene RhoGD12. (2005, October 7). NewsRx.com, p. 72.Primary Research Article
Titus, B., Frierson, H.F., Conaway, M., Ching, K., Guise, T., Chirgwin, J., Hampton, G., Theodorescu, D. (2005). Endothelin Axis Is a Target of the Lung Metastasis Suppressor Gene Rho GD12. Clinical Cancer Research 65, (16). Retrieved February 11, 2008, from https://mail2.pmc.edu/exchweb/bin/redir.asp?URL=http://cancerres.aacrjournals.org/cgi/reprint/65/16/7320.


Both Posts 1 and 2 discuss bladder cancer and two different genes involved in its formation. I find both articles noteworthy because bladder cancer isn’t one of the cancers that we think of being one of the important ones. In the article entitled “Pee Worthy” it discusses how the discovery of the FHIT gene may have a large role in bladder cancer formation and how they will continue to explore possible gene therapy. Blog 2, “What’s the Bladder? A look into bladder cancer and the tumor suppressor gene RhoGD12 was an interesting find because it linked bladder cancer to lung cancer through a tumor suppressor gene known as RhoGD12, which occurred in late stage bladder cancer.

Both posts have a common event which is bladder cancer. Post 1 discusses a main gene involved and post 2 discusses bladder cancer at its end stages and what other genes may play a role. This relates back to many discussions in class on how a mutation of a gene at any point in the cell cycle may cause a mutation. Also how one cancer may lead to another due to metastasis?

There wasn’t much in common between the two blogs except they discuss the same type of cancer and they both involve a gene mutation. Both articles are doing continued research to treat the cancers.

Some questions that still remain regarding both articles are
1. How will gene therapy to the RhogD12 and the FHIT gene help in treating bladder cancer
2. What other cancers may be caused by the metastasis of bladder cancer other than lung cancer.