Resistance to Drugs found in Lung cancers.....

by CharlesC

Posted by Christina

News Article:Health Day (Apr 26, 2007)"Scientists spot mechanism behind lung cancer drug resistance.

"Primary Scientific News Article:Science (May18, 2007) Vol.316.no.5827,pp1039-1043

Posted by cadeta

News Article:Impaired gene helps non-small cell lung cancer resist drug, Biotech Business Week 2006.

Primary ArticleFunctional characterization of the candidate tumor suppressor gene NPRL2/G21 located in 3p21.C3. Cancer research 64, 438-6433, September 15, 2004. American Association for Cancer Research.

After reviewing everyone blogs i noticed a similarity between cell proliferation and the discovery of a new therapuetic drug being studied for a particular type of cancer . But their were two articles in the blog that caught my attention . One was titled "Drug Resistant Lung Cancer" by Christina and the other "Genes give clue to lung Cancer" by cadeta. Instead of stating that reaserchers are coming up with a development for a therapuetic drug on cancer, this article discusses how a drug to treat lung cancer can be resistant. In the blog written by christina, it states how researchers developed to understand that a MET amplification was found in lung cancer patients that had developed a drug resistance to the two growth factor receptor kinase inhibitors. These kinase inhibitors have shown in recent studies that they may help with the treatment in lung cancer.
The common molecular event occurs in "Genes give a clue to lung cancer". just like how reaserachers found MET amplification in patients with EGFR, which are becoming resistant to growth factor receptor Kinases inhibitors, the occurance of cell amplification, and resistance to a drug for the treatment in lung cancer but was found in genes. Both of the articles discussses the cell proliferation within tumor supressor genes and the effect on how growth factor receptors play a key role on how the treatment for cancer responds to to them.

After the discovery of a certain gene like NPRL2 having to do with the resistant to lung cancer therapy, will this help with other cancer treatments?

Are their particular growth factor kinases inhibitors, like the ones Gefitinib and erlotinib naturally found in most diagnosed with cancer?