Stopping The Spread of Soft Tissue Sarcoma: Is it Possible?
Chen, C., Cen, L., Chan, C., Hsieh, F., Chen, G., et al. (2007 June 28). Signal transducer and activator of transcription factor 3 is involved in cell growth and survival of human rhabdomyosarcoma and osteosarcoma cells. BMC Cancer, (7) 111.
Does the Estrogen Receptors Beta have an Influential Role in inhibiting the Effects of Ovarian Cancer?
Lazennec, Gwendal (2004). Involvement of Estrogen Receptor β in Ovarian Cancinogenesis. Cancer Research, 64, 5861-5869. Retrieved February 12, 2008, from the World Wide Web:
The article on soft tissue sarcoma was one of the articles that grabbed my attention. I was particularly interested in this article because I was unaware on how Stat3 was involved in tissue. The article described by the soft tissue sarcoma post, illustrates the effect Stat3 has on osteosarcomas, rhabdyomaosarcomas, and other soft tissue sarcoma. It goes on and demonstrates that Stat3 is a proto-oncogene that is highly regulated, meaning that it not always active and knows when to turn on and off. However, when there is a mutation in its pathway it can lead to constant activation, which then causes uncontrolled cell division. Once this happens the cancer develops. Another article that I enjoyed reading was “Does the Estrogen Receptor βeta have an Influential Role in inhibiting the Effects of Ovarian Cancer”? The post on ErbB in ovarian cancer describes how ErbB receptors have a great effect on cancer cells. It continues by describing the difference between ErbB and ErbA receptors. The researchers wanted to know if the two receptors had a different effect on cancer proliferation; in order to find out if both receptors had an effect the researchers introduced both ErbA and ErbB receptors to the infected cells. Once the receptors were added they noticed that ErbA had little effect on cell proliferation, on the other hand ErbB had a great effect on cell proliferation. This proves that ErbB receptors are inhibitors of cancer cells.
In comparing these two posts I think that both bloggers did an excellent job, and they both provided immensive information. The common events discussed in both post was how signal transduction played a vital role in the signal pathway. To illustrate, in the research discussed in the sarcoma post it was found that if there is a mutation that occurs in Stat3 then it will have a massive of uncontrolled cell division. However in the ovarian article it states that the ErbB receptors are inhibitors of cancer cells and slows down cell proliferation. This relates back to what my classmates and I have learned in class, since one of the effects of cancer is due to an effect in signaling pathways “on/off” together these posts prove the importance of careful regulation of signaling pathways in cancer.
The two questions that are still in mind after reading and analyzing both posts are, Does ErbB receptors have an effect on any other type of cancers? and
What is the next step a patient takes if they realize they have sarcoma?
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